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Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents

Synthesis of novel pyrazolo[3,4-d]pyrimidine derivatives as potential anti-breast cancer agents

Authors :
Abd El Hamid, Mohammed K.
Mihovilovic, Marko D.
El-Nassan, Hala B.
Source :
European Journal of Medicinal Chemistry. Nov2012, Vol. 57, p323-328. 6p.
Publication Year :
2012

Abstract

Abstract: A series of new 1-aryl-4-benzylidenehydrazinyl-3-methylsulphanyl-pyrazolo[3,4-d]pyrimidines 6a–p was synthesized. The cytotoxic activity of the newly synthesized compounds against human breast cancer cell line, MCF7 was investigated. Most of the test compounds showed potent antitumor activity comparable to that of doxorubicin. The 1-phenyl series (6a–i) exhibited better antitumor activity than 1-(4-methoxyphenyl) series (6j–p). 4-[2-(4-Fluorobenzylidene)hydrazinyl]-3-(methylsulphanyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (6d) was the most active compound in this study with IC50 equal to 7.5 nM. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
02235234
Volume :
57
Database :
Academic Search Index
Journal :
European Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
83657549
Full Text :
https://doi.org/10.1016/j.ejmech.2012.09.031