Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome.

The article informs about a study on the factors involved in the progression of myelodysplastic syndrome (MDS). The study informs about the mutations of runt homology domain of RUNX1 that as an evident aspect present in the patients with MDS. It includes information on MDS patients as they have C-terminal truncation mutations that lack a transcription regulatory domain and have increased DNA binding through the runt homology domain.