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Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted-1,3,4-thiadiazole derivatives.

Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted-1,3,4-thiadiazole derivatives.

Authors :
Karakuş, Sevgi
Çoruh, Ufuk
Barlas-Durgun, Bilgehan
Vázquez-López, Ezequiel M.
Özbaş-Turan, Suna
Akbuğa, Jülide
Rollas, Sevim
Source :
Marmara Pharmaceutical Journal. May2010, Vol. 14 Issue 2, p84-90. 7p.
Publication Year :
2010

Abstract

In this search, a series of 5-[4-(4-fluorobenzoylamino)phenyl]-2-substitutedamino-1,3,4-thiadiazole ( 2a-g ) and 5-[4-(4-fluorobenzoylamino)phenyl]-4-substituted-2,4-dihydro-3H-1,2,4-triazo-le-3-thione ( 3a-f ) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, 1H-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany]. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13090801
Volume :
14
Issue :
2
Database :
Academic Search Index
Journal :
Marmara Pharmaceutical Journal
Publication Type :
Academic Journal
Accession number :
83525365