Novel Dual Use of Formamide-POCl 3 Mixture for the Efficient, One-Pot Synthesis of Condensed 2 H -Pyrimidin-4-amine Libraries Under Microwave Irradiation.

The novel dual use of formamide-POCl3 mixture for the incorporation of a C-N fragment to form the pyrimidine nucleus and its subsequent chlorination in an efficient, one-pot synthesis of potentially bioactive condensed 2H-pyrimidin-4-amine libraries under microwave irradiation (MWI) is reported. The one-pot microwave-assisted synthetic protocol is high-yielding, ecofriendly, rapid, and novel as well as eliminates intermittent workups. The protocol can be adapted for the library synthesis of series of a condensed pyrimidines. [ABSTRACT FROM PUBLISHER]