Transforming Clinical Trials in Cardiovascular Disease: Mission Critical for Health and Economic Well-being.

The author focuses on the importance and development on the use of randomized controlled trials (RCTs) on research and control of the cardiovascular disease (CVD). He highlights the importance of RCT as the critical tool for the clinical investigation, and mentions the adaptation to RCT at several steps including enrollment characteristics, study of treatments, and investigation of primary endpoints during the clinical trials.