Organocatalytic synthesis of novel purine and pyrimidine acyclic nucleosides

Authors :: Palazzolo, Martín A.
Pérez-Sánchez, María
Iribarren, Adolfo M.
Lewkowicz, Elizabeth S.
Domínguez de María, Pablo
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2012, Vol. 53 Issue 50, p6797-6800. 4p.
Publication Year :: 2012
Abstract: Abstract: Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up procedures. Nucleobases containing aldehydes are catalytically ligated (C–C bond formation) to acetone or to phosphonate-containing ketones by means of pyrrolidine or silica-immobilized piperazine as amine-based organocatalysts. [Copyright &y& Elsevier]

Subjects :: *ORGANOCATALYSIS
*PURINE synthesis
*PYRIMIDINE synthesis
*NUCLEOSIDES
*CHEMICAL bonds
*KETONES

Language :: English
ISSN :: 00404039
Volume :: 53
Issue :: 50
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 83328628
Full Text :: https://doi.org/10.1016/j.tetlet.2012.10.009