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Phylogenetic analysis of isolates from new cases of HBV infection in Southern Italy
- Source :
-
Infection, Genetics & Evolution . Dec2012, Vol. 12 Issue 8, p1591-1596. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: The level of endemicity of hepatitis B virus (HBV) infections in Italy is low and genotype D infections predominant. New HBV strains may however be introduced as a result of movements of people from regions of high endemicity. The aim of the present study was to determine whether strains from new cases of acute hepatitis B detected in southern Italy were due to endemic or new HBV strains. We studied 34 isolates from patients with acute hepatitis B infection, and 35 from chronic hepatitis B patients. A phylogenetic analysis of preS/S region was done by comparing the sequences from the acute and chronic cases with references sequences. The study showed that 44% of strain from acute hepatitis B patients were of genotype A, 53% of genotype D, and 3% of genotype E. The molecular analysis of isolates from acute hepatitis B patients from Sicily showed a change in the local epidemiology of this infection, with an increase in HBV/A infections and a clustering effect for HBV D2, possibly correlated to immigration. The introduction of new genotypes , could have an effect on HBV-correlated diseases due to the different association between genotype, liver disease and response to antiviral therapy. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15671348
- Volume :
- 12
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Infection, Genetics & Evolution
- Publication Type :
- Academic Journal
- Accession number :
- 82840879
- Full Text :
- https://doi.org/10.1016/j.meegid.2012.07.006