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Caspase-3 in the central nervous system: beyond apoptosis
- Source :
-
Trends in Neurosciences . Nov2012, Vol. 35 Issue 11, p700-709. 10p. - Publication Year :
- 2012
-
Abstract
- Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its activation is observed early in neural tube formation and persists during postnatal differentiation of the neural network. Caspase-3 activation, a crucial event of neuronal cell death program, is also a feature of many chronic neurodegenerative diseases. This traditional apoptotic function of caspase-3 is challenged by recent studies that reveal new cell death-independent roles for mitochondrial-activated caspase-3 in neurite pruning and synaptic plasticity. These findings underscore the need for further research into the mechanism of action and functions of caspase-3 that may prove useful in the development of novel pharmacological treatments for a diverse range of neurological disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01662236
- Volume :
- 35
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Trends in Neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 82839628
- Full Text :
- https://doi.org/10.1016/j.tins.2012.06.004