Back to Search
Start Over
Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned 23Na/1H resonator systems.
- Source :
-
Physics in Medicine & Biology . 11/7/2012, Vol. 57 Issue 21, p6929-6946. 18p. - Publication Year :
- 2012
-
Abstract
- A double-tuned 23Na/¹H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. ¹H-diffusion-, ¹H perfusion, ¹H T2-, ¹H arterial blood flow- and 23Na spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal 23Na was detected in hypoperfused stroke tissue which exhibited a low ¹H apparent diffusion coefficient (ADC) and no changes in ¹H T2 relaxation time during transient ischemia, while 23Na increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned ¹H/23Na birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear 23Na/¹H MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high 23Na at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear 23Na/¹HMRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319155
- Volume :
- 57
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Physics in Medicine & Biology
- Publication Type :
- Academic Journal
- Accession number :
- 82832363
- Full Text :
- https://doi.org/10.1088/0031-9155/57/21/6929