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Staphylococcus aureus infections in the early period after lung transplantation: Epidemiology, risk factors, and outcomes
- Source :
-
Journal of Heart & Lung Transplantation . Nov2012, Vol. 31 Issue 11, p1199-1206. 8p. - Publication Year :
- 2012
-
Abstract
- BACKGROUND: Staphylococcus aureus infections among lung transplant recipients are poorly studied. METHODS: We conducted a 5-year retrospective study of the epidemiology, clinical manifestations, risk factors, and outcomes of patients infected with S aureus within the first 90 days after lung transplantation. RESULTS: An S aureus infection developed in 109 of 596 lung transplant (18%) recipients. Methicillin-susceptible S aureus (MSSA; 62%) was more common than methicillin-resistant S aureus (MRSA; 38%); however, the proportion of infections caused by MRSA increased over time. Pneumonia (48%) was the most common infection, followed by tracheobronchitis (26%), bacteremia (12%), intrathoracic infections (7%), and skin/soft tissue infections (7%). Risk factors included mechanical ventilation for >5 days and isolation of S aureus from recipients’ sterility cultures. Patients with MRSA cultured from the nares or respiratory tract at the time of transplant were at an increased risk for MRSA infection (p<0.0001 and p=0.02, respectively). Infected patients required longer hospital and intensive care unit stays (p<0.0001 for both), but the 30- and 90-day mortality rates from the onset of infection were only 7% and 12%, respectively. However, infected patients had higher rates of acute and chronic rejection at 1 (p=0.048) and 3 years (p=0.002), and higher rates of mortality at 1 (p=0.058) and 3 years (p=0.009). Conclusions: S aureus infections within the first 90 days of lung transplant were associated with low short-term mortality but increased long-term rates of mortality and acute and chronic rejection. Future studies are needed to explore the utility of S aureus eradication strategies in reducing disease burden and improving outcomes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10532498
- Volume :
- 31
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Heart & Lung Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 82428466
- Full Text :
- https://doi.org/10.1016/j.healun.2012.08.012