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Optimization of [11C]DASB-synthesis: Vessel-based and flow-through microreactor methods
- Source :
-
Applied Radiation & Isotopes . Nov2012, Vol. 70 Issue 11, p2615-2620. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: The intention for the present study was to implement a microfluidic set-up for N-11C-methylations in a flow-through microreactor device with [11C]DASB as model-compound and [11C]CH3I and [11C]CH3OTf, respectively, as 11C-methylation agents. Due to an observed “aging” effect of the 11C-methylation agents'' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [11C]DASB was reduced (34±1min) and RCY was increased to 45.1±4.6% (EOB; 5.2±0.95GBq EOS). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09698043
- Volume :
- 70
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Applied Radiation & Isotopes
- Publication Type :
- Academic Journal
- Accession number :
- 82062638
- Full Text :
- https://doi.org/10.1016/j.apradiso.2012.08.001