Confidence interval calculation for a sequential clinical trial of binary responses.

Consider a sequential test applied to two streams of binary responses in a comparative clinical trial. After the completion of such a trial Woodroofe's (1992) technique for accurate confidence interval estimation for a treatment difference can be applied. In this paper the technique is extended to provide confidence intervals for the individual absolute success probabilities of the two treatments in the trial, for which no current methodology exists. Accuracy is explored by simulation of coverage probabilities and individual confidence limit probabilities. The simulations concern a triangular test and an O'Brien & Fleming test. [ABSTRACT FROM AUTHOR]