Novel Synthesis of trans-4,6-Diaryl-5-nitropiperidin-2-ones via Four-Component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Dimethyl Malonate, and Formamide.

An effective and practical method has been developed for the diversity-oriented synthesis of trans-4,6-diaryl-5-nitropiperidin- 2-ones via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, dimethyl malonate, and formamide for the generation of a wide range of structurally interesting and pharmacologically significant compounds. It is worth mentioning that in the course of this reaction, the formation of products was highly stereoselective [ABSTRACT FROM AUTHOR]