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Dextran and gelatin based photocrosslinkable tissue adhesive
- Source :
-
Carbohydrate Polymers . Nov2012, Vol. 90 Issue 4, p1428-1436. 9p. - Publication Year :
- 2012
-
Abstract
- Abstract: A two-component tissue adhesive based on biocompatible and bio-degradable polymers (oxidized urethane dextran (Dex-U-AD) and gelatin) was prepared and photocrosslinked under the ultraviolet (UV) irradiation. The adhesive could adhere to surface of gelatin, which simulated the human tissue steadily. The structures of above Dex-U-AD were characterized by FTIR, 1H NMR spectroscopy and XRD. The adhesion property of result products was evaluated by lap-shear test. The maximum adhesion strength could reach to 4.16±0.72MPa which was significantly higher than that of fibrin glue. The photopolymerization process of Dex-U-AD/gelatin was monitored by real time infrared spectroscopy (RTIR). It took less than 5min to complete the curing process. The cytotoxicity of Dex-U-AD/gelatin also was evaluated which indicated that Dex-U-AD/gelatin gels were nontoxic to L929 cell. The relationship between all the above-mentioned properties and degree of oxidization of Dex-U-AD was assessed. The obtained products have the potential to serve as tissue adhesive in the future. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01448617
- Volume :
- 90
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 79682084
- Full Text :
- https://doi.org/10.1016/j.carbpol.2012.07.011