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Epidemiological designs for vaccine safety assessment: Methods and pitfalls

Authors :
Andrews, Nick
Source :
Biologicals. Sep2012, Vol. 40 Issue 5, p389-392. 4p.
Publication Year :
2012

Abstract

Abstract: Three commonly used designs for vaccine safety assessment post licensure are cohort, case-control and self-controlled case series. These methods are often used with routine health databases and immunisation registries. This paper considers the issues that may arise when designing an epidemiological study, such as understanding the vaccine safety question, case definition and finding, limitations of data sources, uncontrolled confounding, and pitfalls that apply to the individual designs. The example of MMR and autism, where all three designs have been used, is presented to help consider these issues. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
10451056
Volume :
40
Issue :
5
Database :
Academic Search Index
Journal :
Biologicals
Publication Type :
Academic Journal
Accession number :
79558634
Full Text :
https://doi.org/10.1016/j.biologicals.2011.08.010