Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis

Abstract: Interest in using 68Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO2-based 68Ge/68Ga generators and develop an optimized automation strategy to synthesize [68Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of 68Ge/68Ga generators and automation strategies to comply with regulatory issues for clinical use. [Copyright &y& Elsevier]