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Prostaglandin E2 and cAMP promote B lymphocyte class switching to IgG1
- Source :
-
Immunology Letters . Dec2002, Vol. 84 Issue 3, p191. 8p. - Publication Year :
- 2002
-
Abstract
- Prostaglandins of the E series (PGE) have traditionally been considered as suppressive for immune responses; however, recent data suggest that PGE channels the immune response towards a T helper 2 type response and production of selected immunoglobulin isotypes. Herein, we present data showing that PGE2 and other agents that induce intracellular rises in cAMP significantly increased B lymphocyte IgG1 production (up to sevenfold). PGE2 acted on small resting B cells and on uncommitted B cells expressing high levels of surface IgM to increase the number of cells secreting IgG1. PGE2 even increased IgG1 synthesis by purified B cells in the absence of exogenous IL-4. Finally, PGE2 synergized with IL-4 to induce germline γ1 transcripts through the switch region. This transcription is required for isotype switching. These data support the hypothesis that PGE2 acts on uncommitted resting B cells at the level of germline γ1 transcription to promote class switching to IgG1. PGE2 is an important regulator of the immune response, shifting the balance towards a T helper type 2 response, directing selection of the isotypes produced, and promoting memory cell formation. [Copyright &y& Elsevier]
- Subjects :
- *PROSTAGLANDIN E1
*PROSTAGLANDINS E
Subjects
Details
- Language :
- English
- ISSN :
- 01652478
- Volume :
- 84
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Immunology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7912316
- Full Text :
- https://doi.org/10.1016/S0165-2478(02)00185-2