LATE COMPONENT ERPs ARE ASSOCIATED WITH THREE SYNDROMES IN SCHIZOPHRENIA.

Previous studies have revealed various abnormalities in late-component ERP amplitude and latency in schizophrenia, considered as a diagnostic category. The aim of this study was to investigate the within-sample associations between late-component ERPs and three primary syndromes of schizophrenia — Reality Distortion, Psychomotor Poverty and Disorganisation. Subjects included 40 schizophrenics and 40 age and sex matched nonpsychiatric controls. Auditory ERPs (N100, N200, P200, P300) were elicited using an auditory oddball paradigm. Between-group analyses of target data showed reduced N100, N200 and P300 amplitude, increased P200 amplitude and delayed N200 latency in schizophrenics compared to controls. For non-target data, schizophrenics showed similarly reduced N100 amplitude and delayed N200 latency. Within-group analyses of target data showed that the three syndromes (determined by principal component analysis of PANSS ratings) were differentiated by ERP latency, but not amplitude (Disorganisation — delayed left hemisphere P200 and P300 latency; Reality Distortion -earlier global, midline and left hemisphere N200 latency; Psychomotor Poverty -delayed posterior N100 latency). Notably, only Disorganisation showed a divergent pattern of associations with non-target ERP data: reduced P200 amplitude and delayed N100 latency. This study highlights the potential utility of exploring symptom profiles in elucidating specific patterns of brain dysfunction in schizophrenia. [ABSTRACT FROM AUTHOR]