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Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa
- Source :
-
Biochemical & Biophysical Research Communications . Aug2012, p89-93. 5p. - Publication Year :
- 2012
-
Abstract
- Abstract: Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8+ T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8+ T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal dehydrogenase in the draining lymph nodes following the i.m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell response in the gut-mucosal compartment following the i.m. Adv vaccination. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 79034980
- Full Text :
- https://doi.org/10.1016/j.bbrc.2012.07.056