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Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models
- Source :
-
Cytokine & Growth Factor Reviews . Aug2002, Vol. 13 Issue 4/5, p341. 15p. - Publication Year :
- 2002
-
Abstract
- Expression of inflammatory cytokines is augmented in the joints of patients with rheumatoid arthritis (RA). We found that cytokine levels are also elevated in the joints of a mouse arthritis model, human T-cell leukemia virus type I (HTLV-I) transgenic (Tg) mouse. Depletion of IL-1 by gene targeting greatly reduced the incidence of the disease, indicating the importance of this cytokine in the development of arthritis. Furthermore, IL-1 receptor antagonist (IL-1Ra)-deficient mice develop autoimmunity and arthritis spontaneously. These observations suggest that excess IL-1 signaling the causes autoimmunity. We show that IL-1 activates the immune system non-specifically by inducing CD40L and OX40 co-signaling molecules on T cells. In this review, the roles of IL-1 in the development of autoimmunity and arthritis in mouse models will be discussed. [Copyright &y& Elsevier]
- Subjects :
- *CYTOKINES
*HTLV-I
*RHEUMATOID arthritis
Subjects
Details
- Language :
- English
- ISSN :
- 13596101
- Volume :
- 13
- Issue :
- 4/5
- Database :
- Academic Search Index
- Journal :
- Cytokine & Growth Factor Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 7872279
- Full Text :
- https://doi.org/10.1016/S1359-6101(02)00021-7