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Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2002, Vol. 12 Issue 19, p2733. 4p. - Publication Year :
- 2002
-
Abstract
- N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-d-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25–2 μg/mL. [Copyright &y& Elsevier]
- Subjects :
- *PYRROLIDINE
*ANTIFUNGAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 12
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7867424
- Full Text :
- https://doi.org/10.1016/S0960-894X(02)00534-6