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The role of nitric oxide in the proconvulsant effect of δ-opioid agonist SNC80 in mice
- Source :
-
Neuroscience Letters . Aug2002, Vol. 329 Issue 2, p237. 3p. - Publication Year :
- 2002
-
Abstract
- The involvement of nitric oxide (NO) in modulation of seizure susceptibility by δ-opioid agonist (+)-4-((alpha R)-alpha-((2S, 5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N, N-diethyl-benzamide (SNC80) was examined in mice. Systemic administration of SNC80 (0.1–5 mg/kg, intraperitoneally (i.p.)) decreased the threshold for clonic seizures induced by pentylenetetrazole. The non-specific NO synthase (NOS) inhibitor, NG-nitro-l-arginine methyl ester (3–20 mg/kg, i.p.), but not the specific inducible NOS inhibitor, aminoguanidine (50 and 100 mg/kg, i.p.) inhibited the proconvulsant effect of SNC80. On the other hand, NO substrate, l-arginine (30 and 60 mg/kg, i.p.) potentiated the proconvulsant effect of a lower dose of SNC80 (0.5 mg/kg). These results support the involvement of NO, produced by constitutive NOS, in the proconvulsant effect of the δ-opioid agonist. [Copyright &y& Elsevier]
- Subjects :
- *NITRIC-oxide synthases
*OPIOIDS
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 329
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7859282
- Full Text :
- https://doi.org/10.1016/S0304-3940(02)00417-2