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Detection of Antiphospholipid Antibody in Children With Henoch-Schönlein Purpura and Central Nervous System Involvement
- Source :
-
Pediatric Neurology . Sep2012, Vol. 47 Issue 3, p167-170. 4p. - Publication Year :
- 2012
-
Abstract
- Abstract: To explore the mechanisms of central nervous system involvement in children with Henoch-Schönlein purpura, levels of lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein I antibodies in serum and cerebrospinal fluid were determined in 46 cases of Henoch-Schönlein purpura with central nervous system involvement. Results indicated that Henoch-Schönlein purpura with central nervous system involvement produced a higher total percentage of antiphospholipid antibodies in serum and cerebrospinal fluid, compared with viral encephalitis control subjects (76.1% vs 10.0% and 71.7% vs 0.0%, respectively; P < 0.05). Henoch-Schönlein purpura may be associated with antiphospholipid syndrome or antiphospholipid antibodies, which may account for the neurologic damage in Henoch-Schönlein purpura. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08878994
- Volume :
- 47
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Pediatric Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 78431736
- Full Text :
- https://doi.org/10.1016/j.pediatrneurol.2012.05.024