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Drug discovery in the age of systems biology: the rise of computational approaches for data integration
- Source :
-
Current Opinion in Biotechnology . Aug2012, Vol. 23 Issue 4, p609-616. 8p. - Publication Year :
- 2012
-
Abstract
- The increased availability of large-scale open-access resources on bioactivities of small molecules has a significant impact on pharmacology facilitated mainly by computational approaches that digest the vast amounts of data. We discuss here how computational data integration enables systemic views on a drug''s action and allows to tackle complex problems such as the large-scale prediction of drug targets, drug repurposing, the molecular mechanisms, cellular responses or side effects. We particularly focus on computational methods that leverage various cell-based transcriptional, proteomic and phenotypic profiles of drug response in order to gain a systemic view of drug action at the molecular, cellular and whole-organism scale. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09581669
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 78431447
- Full Text :
- https://doi.org/10.1016/j.copbio.2011.11.010