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Clinical implication of urinary tubular markers in the early stage of nephropathy with type 2 diabetic patients
- Source :
-
Diabetes Research & Clinical Practice . Aug2012, Vol. 97 Issue 2, p251-257. 7p. - Publication Year :
- 2012
-
Abstract
- Abstract: Aim: The aim of this study was to evaluate the association of urinary tubular markers, interleukin-18 (IL-18) and angiotensinogen with albuminuria in early nephropathy of type 2 diabetics. Methods: Urine levels of tubular markers (kidney injury molecule [KIM]-1, neutrophil gelatinase-associated lipocalin [NGAL] and liver-type fatty acid-binding protein [L-FABP]), proinflammatory marker (IL-18), and a marker of intrarenal renin-angiotensin system (RAS) status (angiotensinogen) were determined in 118 patients with type 2 diabetes mellitus and 25 non-diabetic controls with estimated glomerular filtration rate (eGFR) ≥60mL/min/1.73m2. Results: Urinary levels of KIM-1, NGAL, IL-18 and angiotensinogen were significantly higher in macroalbuminuria group compared with control and normo- and microalbuminuria groups but not significantly different between control and normoalbuminuria group. Urinary tubular markers were positively correlated with urinary IL-18 and angiotensinogen, respectively. The urinary albuminuria was correlated with all investigated urinary markers in univariate analysis. After adjusting for several clinical parameters, urinary KIM-1, NGAL and angiotensinogen were significantly associated with albuminuria. Conclusions: The results of this study suggest that urinary tubular markers may be independently associated with albuminuria in the early stage of nephropathy in type 2 diabetics (eGFR ≥60mL/min/1.73m2) and may reflect inflammatory processing and the activation of the intrarenal RAS. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 97
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 78429794
- Full Text :
- https://doi.org/10.1016/j.diabres.2012.02.019