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Structure–activity relationships of non-imidazole H3 receptor ligands. Part 1

Authors :
Faghih, Ramin
Dwight, Wesley
Gentles, Robert
Phelan, Kathleen
Esbenshade, Timothy A.
Ireland, Lynne
Miller, Thomas R.
Kang, Chae-Hee
Fox, Gerard B.
Gopalakrishnan, Sujatha M.
Hancock, Arthur A.
Bennani, Youssef L.
Source :
Bioorganic & Medicinal Chemistry Letters. Aug2002, Vol. 12 Issue 15, p2031. 4p.
Publication Year :
2002

Abstract

SAR studies for novel non-imidazole containing H3 receptor antagonists with high potency and selectivity for rat H3 receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds. [Copyright &y& Elsevier]

Subjects

Subjects :
*IMIDAZOLES
*PIPERAZINE

Details

Language :
English
ISSN :
0960894X
Volume :
12
Issue :
15
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
7837567
Full Text :
https://doi.org/10.1016/S0960-894X(02)00309-8