Dual-capillary electroencapsulation of mesoporous silicon drug carrier particles for controlled oral drug delivery

Abstract: The feasibility of electroencapsulation of mesoporous silicon (PSi) micro- and nanoparticles as a method to seal the PSi particles in mechanically processable solid units, and to facilitate time and site specific drug release from the pores of PSi particles, is of interest in the present work. Suitable microcapsules and micromatrix particles were produced in a single-step process using a setup with two electrospraying nozzles kept at high electric potentials of opposite polarities. The structures of the produced particles were analyzed by microscope and X-ray micro- and nanotomography imaging, and optimization of the electroencapsulation process production efficiency is discussed. [Copyright &y& Elsevier]