Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction.

The article focuses on a study which examined the possible protective effect of proteasome inhibitor, bortezomib, against ventilator-induced diaphragm dysfunction. The study included anesthetized rats that were submitted to controlled mechanical ventilation while receiving bortezomib or saline. It found that bortezomib partially protects the diaphragm from controlled mechanical ventilation-induced diaphragm contractile dysfunction but did not prevent atrophy.