ChemInform Abstract: Enantioselective Construction of Spiro[2H-pyran-3,4′-indoline] by a Systematic Michael/Reduction/Cyclization Sequence Triggered by the Asymmetric Conjugate Addition of Ketones to Isatylidenemalononitriles.

The Michael addition reactions are performed with excellent enantioselectivities in the presence of a cinchona-based chiral primary amine and L-camphoric acid as an effective catalyst system. [ABSTRACT FROM AUTHOR]