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An efficient one-step chemoselective reduction of alkyl ketones over aryl ketones in β-diketones using LiHMDS and lithium aluminium hydride
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Aug2012, Vol. 53 Issue 35, p4651-4653. 3p. - Publication Year :
- 2012
-
Abstract
- Abstract: β-Hydroxy ketones were synthesized in one-pot from β-diketones by reducing alkyl ketones chemoselectively by keeping aryl ketone intact. Initially, β-diketones were enolized using LiHMDS and later alkyl ketone was chemoselectively reduced efficiently by lithium aluminium hydride. This method produces β- hydroxyl ketones from the corresponding β-diketones in high yield. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 53
- Issue :
- 35
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 78169326
- Full Text :
- https://doi.org/10.1016/j.tetlet.2012.06.057