Bimetallic complexes constructed from asymmetrical N,N′-bis(substituted)-oxamide: Cytotoxicities, and reactivities towards DNA and protein

Abstract: A new asymmetrical N,N′-bis(substituted)oxamide ligand, N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide (C13H18N3O3Cl·H2O, H 3 L) and its two binuclear complexes [Cu2L(H2O)(bpy)](ClO4)·CH3OH (1) and [Ni2L(bpy)2](ClO4) (2) [bpy = 2,2′-bipyridine] have been synthesized and characterized by X-ray single-crystal diffraction. In the crystal structure, H 3 L adopting a transoid conformation occurs as a neutral molecule linked with a water molecule by an intermolecular hydrogen bond. In the two complexes, the cis-L3− ligand bridges two metal ions with the corresponding separations of 5.2032(15) Å (1) and 5.2466(7) Å (2), respectively. In vitro cytotoxic activities, and the reactivities of the three compounds towards DNA and protein are investigated. [Copyright &y& Elsevier]