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The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: A structural equation modeling approach
- Source :
-
Biological Psychology . Sep2012, Vol. 91 Issue 1, p111-119. 9p. - Publication Year :
- 2012
-
Abstract
- Abstract: Here we examine the effects of both self-reported and independent observer-reported environmental risk indices, the serotonin transporter gene promoter (5HTTLPR) polymorphism, and their interaction on self-esteem. This trait was assessed during early and mid adolescence (mean age=14 and 16.5, respectively) and young adulthood (mean age=21.8) in a prospective cohort of 1214 unrelated participants in the Longitudinal Study of Adolescent Health (Add Health). Using structural equation modeling we identified a gene–environment (G×E) interaction using observer-report but not self-report measures of environmental stress exposure during adolescence: 5HTTLPR genotype and observer-reports of home and neighborhood quality (HNQ) during adolescence interacted to predict self-esteem levels in young adulthood (p <.004). Carriers of the s allele who lived in poor HNQ conditions during adolescence reported lower self-esteem in young adulthood than those with a good HNQ during adolescence. In contrast, among individuals with the l/l genotype, adolescent HNQ did not predict adulthood self-esteem. Genes may moderate the effect of adolescent environmental conditions on adulthood self-esteem. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03010511
- Volume :
- 91
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biological Psychology
- Publication Type :
- Academic Journal
- Accession number :
- 78145434
- Full Text :
- https://doi.org/10.1016/j.biopsycho.2012.05.004