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Breast Cancer Index predicts pathological complete response and eligibility for breast conserving surgery in breast cancer patients treated with neoadjuvant chemotherapy.
- Source :
-
Annals of Oncology . Aug2012, Vol. 23 Issue 8, p2046-2052. 7p. 3 Charts, 2 Graphs. - Publication Year :
- 2012
-
Abstract
- Background The aim of neoadjuvant chemotherapy is to increase the likelihood of successful breast conservation surgery (BCS). Accurate identification of BCS candidates is a diagnostic challenge. Breast Cancer Index (BCI) predicts recurrence risk in estrogen receptor + lymph node − breast cancer. Performance of BCI to predict chemosensitivity based on pathological complete response (pCR) and BCS was assessed. Methods Real-time RT-PCR BCI assay was conducted using tumor samples from 150 breast cancer patients treated with neoadjuvant chemotherapy. Logistical regression and c-index were used to assess predictive strength and additive accuracy of BCI beyond clinicopathologic factors. Results BCI classified 42 % of patients as low, 35 % as intermediate and 23 % as high risk. Low BCI risk group had 98.4 % negative predictive value (NPV) for pCR and 86 % NPV for BCS. High versus low BCI group had a 34 and 5.8 greater likelihood of achieving pCR and BCS, respectively (P = 0.0055; P = 0.0022). BCI increased c-index for pCR (0.875–0.924; P = 0.017) and BCS prediction (0.788–0.843; P = 0.027) beyond clinicopathologic factors. Conclusions BCI significantly predicted pCR and BCS beyond clinicopathologic factors. High NPVs indicate that BCI could be a useful tool to identify breast cancer patients who are not eligible for neoadjuvant chemotherapy. These results suggest that BCI could be used to assess both chemosensitivity and eligibility for BCS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09237534
- Volume :
- 23
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Annals of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 78117403
- Full Text :
- https://doi.org/10.1093/annonc/mdr550