Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy.

The article discusses the molecule inhibitors of enzymes with the structural and chemical diversity of topoisomerase II modulators as anticancer agents. It mentions the development of chemical families of anticancer drugs which are classified as topoisomerase II poisons including epipodopodophyllotoxins, anthracyclines, and acridines. It says that potent cytotoxic agents are used to limit tumor growth and metastasis.