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Asymmetric Pd-NHC*-catalyzed coupling reactions.
- Source :
-
Pure & Applied Chemistry . Aug2012, Vol. 84 Issue 8, p1741-1748. 8p. - Publication Year :
- 2012
-
Abstract
- Very high asymmetric inductions result in the Pd-catalyzed intramolecular arylation of amides to give 3,3-disubstituted oxindoles when new in situ-generated chiral N-heterocyclic carbene (NHC*) ligands are employed. Structural studies show that conformational locking to minimize allylic strain is the key to understanding the function of these ligands. New applications of these ligands in the frontier area of asymmetric coupling reactions involving C(sp³)--H bonds are detailed. Highly enantioenriched fused indolines are accessible using either preformed- or in situ-generated Pd-NHC* catalysts. Remarkably, this occurs at high temperature (140--160 °C) via excellent asymmetric recognition of an enantiotopic C--H bond in an unactivated methylene unit. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00334545
- Volume :
- 84
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Pure & Applied Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 78093258
- Full Text :
- https://doi.org/10.1351/PAC-CON-12-02-10