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Survey of Japanese infants younger than 3 months who were treated with oseltamivir for influenza: Safety of oseltamivir treatment.
- Source :
-
Scandinavian Journal of Infectious Diseases . Aug2012, Vol. 44 Issue 8, p605-609. 5p. 3 Charts. - Publication Year :
- 2012
-
Abstract
- Background: Young infants with influenza virus infection are frequently hospitalized, and are at risk of serious complications including death. With the emergence of pandemic influenza A/H1N1 2009, oseltamivir was approved for use in Europe and the USA, including use in infants aged < 3 months. However, few data are available regarding the safety of oseltamivir treatment for influenza in infants aged < 3 months. Methods: The clinical data from Japanese infants aged < 3 months with laboratory-confirmed influenza virus infections, who were treated with oseltamivir between October 2009 and April 2011, were collected and analyzed. Results: Forty-four infants were included in the study. The median age was 1 month (range 4 days to 2 months) and median body weight was 4.5 kg (range 2.6-7.6 kg). Thirty-eight infants (86%) had no underlying diseases. The most common presenting symptom was fever (42 infants, 95%). There were no cases of influenza-associated encephalopathy or myocarditis. The median time between the onset of influenza symptoms and initiation of oseltamivir treatment was 0 days (range 0-7 days), with treatment initiated within 1 day in 40 infants (91%). The oseltamivir dose was 1.5-2 mg/kg twice daily in 98% of infants. No serious adverse events were identified during treatment. All infants recovered completely. Conclusions: Treatment of influenza with oseltamivir 1.5-2 mg/kg twice daily may be safe in infants aged < 3 months. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00365548
- Volume :
- 44
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Scandinavian Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 77907686
- Full Text :
- https://doi.org/10.3109/00365548.2012.669844