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A Facile Approach to Fabricate Water-soluble Au-Fe3O4 Nanoparticle for Liver Cancer Cells Imaging.
- Source :
-
Chinese Journal of Chemistry . Jul2012, Vol. 30 Issue 7, p1387-1392. 6p. - Publication Year :
- 2012
-
Abstract
- Au-Fe3O4 nanoparticles were widely used as nanoplatforms for biologic applications through readily further functionalization. Dopamine (DA)-coated superparamagnetic iron oxide (SPIO) nanoparticles (DA@Fe3O4) have been successfully synthesized using a one-step process by modified coprecipitation method. Then 2-3 nm gold nanoparticles were easily conjugated to DA@Fe3O4 nanoparticles by the electrostatic force between gold nanoparticles and amino groups of dopamine to afford water-soluble Au-Fe3O4 hybrid nanoparticles. A detailed investigation by dynamic light scatting (DLS), transmission electron microscopy (TEM), fourier transform infrared (FT-IR) and X-ray diffraction (XRD) were performed in order to characterize the physicochemical properties of the hybrid nanoparticles. The hybrid nanoparticles were easily functionalized with a targeted small peptide A54 (AGKGTPSLETTP) and fluorescence probe fluorescein isothiocyanate (FITC) for liver cancer cell BEL-7402 imaging. This simple approach to prepare hybrid nanoparticles provides a facile nanoplatform for muti-functional derivations and may be extended to the immobilization of other metals or bimolecular on SPIO surface. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 30
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 77872772
- Full Text :
- https://doi.org/10.1002/cjoc.201100692