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Amniotic fluid matrix metalloproteinase-9 and interleukin-6 in predicting intra-amniotic infection
- Source :
-
Obstetrics & Gynecology . Jan2002, Vol. 99 Issue 1, p80. 5p. - Publication Year :
- 2002
-
Abstract
- OBJECTIVE: To assess the potential role of amniotic fluid (AF) matrix metalloproteinase-9 and interleukin-6 in predicting intra-amniotic infection.METHODS: Eighty-four women with singleton gestations with preterm contraction, preterm labor, preterm premature rupture of membranes, or clinical suspicion of intra-amniotic infection were studied. Amniotic fluid was obtained by transabdominal amniocentesis before starting any treatment. Intra-amniotic infection was defined as the presence of a positive AF culture. Amniotic fluid glucose concentration, leukocytes, matrix metalloproteinase-9, and interleukin-6 were determined.RESULTS: Amniotic fluid matrix metalloproteinase-9 and interleukin-6 levels were significantly higher in women with intra-amniotic infection than in those without. With intra-amniotic infection, levels of matrix metalloproteinase-9 significantly correlated with interleukin-6 (r = 0.813, P < .001). Each of matrix metalloproteinase-9 and interleukin-6 significantly correlated with AF leukocytes and inversely correlated with AF glucose. Using AF cutoff levels of 13.6 ng/mL for matrix metalloproteinase-9 and 11.4 ng/mL for interleukin-6, the sensitivity, specificity, and positive and negative predictive values for diagnosing intra-amniotic infection were 77% versus 73%, 100% versus 79%, 100% versus 61%, and 90% versus 86%, respectively. Combining AF matrix metalloproteinase-9 with interleukin-6 slightly improved the sensitivity and the negative predictive values in diagnosing intra-amniotic infection.CONCLUSIONS: Amniotic fluid matrix metalloproteinase-9 and interleukin-6 are significantly elevated in women with intra-amniotic infection. Amniotic fluid matrix metalloproteinase-9 is an accurate biochemical marker in predicting intra-amniotic infection with better sensitivity, specificity, and positive and negative predictive values than interleukin-6. [Copyright &y& Elsevier]
- Subjects :
- *AMNIOTIC liquid
*METALLOPROTEINASES
*INTERLEUKIN-6
Subjects
Details
- Language :
- English
- ISSN :
- 00297844
- Volume :
- 99
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 7782410
- Full Text :
- https://doi.org/10.1097/00006250-200201000-00016