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Pelvic surgery and hospitalization among Chilean women after nonsurgical sterilization with quinacrine pellets between 1977 and 1989
- Source :
-
Contraception . Aug2012, Vol. 86 Issue 2, p106-109. 4p. - Publication Year :
- 2012
-
Abstract
- Abstract: Background: Concern about quinacrine lingers because of its carcinogenic effects in rats. We describe results of long-term follow-up of women who underwent quinacrine pellet sterilization in Chile between 1977 and 1989 (N=1492). Methods: We interviewed the women or relatives in five rounds of data collection between 1991–1993 and 2006–2007, and reviewed hospital records. Median follow-up was 18.5 years; total person-time was 23,894 woman-years. This analysis focuses on pelvic and abdominal surgeries and conditions. We used survival analysis to estimate the 15-year cumulative probability of hysterectomy, other pelvic surgical procedures and relevant adverse events. Results: Uterine fibroids were by far the most common gynecologic condition, reported by 11% of the cohort. Surgical procedures were recorded for 15% of the cohort; hysterectomy was the most frequent procedure (10%), followed by salpingectomy (2%). The 15-year probability of any pelvic or abdominal procedure was 14.7 per 100 women (95% confidence interval 12.4–16.9). The probability of hysterectomy was 9.3 per 100 women (95% confidence interval 7.4–11.1). Number of quinacrine insertions had little impact on the probabilities. Conclusion: During long-term follow-up of women who received quinacrine pellets for nonsurgical sterilization, the incidence of noncancer adverse outcomes was not unusually high, and no alarming patterns emerged. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00107824
- Volume :
- 86
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Contraception
- Publication Type :
- Academic Journal
- Accession number :
- 77733241
- Full Text :
- https://doi.org/10.1016/j.contraception.2011.11.072