GLOMERULOPATIE JAKO PRZYCZYNA SCHYŁKOWEJ NIEWYDOLNOŚCI NEREK U DZIECI - DANE NA PODSTAWIE POLSKIEGO REJESTRU DZIECI LECZONYCH NERKOZASTĘPCZO (2000-2007).

Introduction: The proportion of glomerulopathies as a cause of end-stage renal failure has been increasing in several regions of the world in recent years. Aim of study: An analysis of the contribution of glomerulopathies in 803 children (362 girls and 441 boys) on renal replacement therapy recorded between 2000-2007 in the Polish Renal Replacement Therapy Registry. Results: Among 803 cases, 37.5% were diagnosed as glomerulopathy. The majority were classified as primary glomerulonephritis (22.8%). Secondary glomerulonephritis due to systemic disease was diagnosed in 8.5% of cases and congenital glomerulopathy in 6.2%. The most frequent diagnosis among primary glomerulonephritis was FSGS (35%) and RPGN (13%). There was no differences in sex distribution between glomerulopathy groups. The mean age at start of RRT in glomerulopathy group was 11.4±5 years and did not differ from the whole population (10.4±5.5 years). Patients with congenital nephrotic syndrome started RRT at younger age (7.1±6.4 years, p <0.05). Time to transplant in children with glomerulopathy did not differ significantly compared to the whole population: median observation time was 24.2 months vs 26 months. During 8 years of follow-up 59 deaths were observed: 6 deaths in 181 children with primary glomerulopathies, 4 deaths in 38 children with congenital nephrotic syndrome and 11 deaths in 37 children with secondary glomerulonephrities. Conclusions: Glomerulopathies are the second cause of end-stage renal failure in children after congenital urinary disorders. The worst prognosis and highest case-fatality rate was observed in secondary glomerulopathy group. [ABSTRACT FROM AUTHOR]