First crystallographic signature of the highly ordered supramolecular helical assemblage from a tripeptide containing a non-coded amino acid

Authors :: Haldar, Debasish
Maji, Samir Kumar
Sheldrick, William S.
Banerjee, Arindam
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2002, Vol. 43 Issue 14, p2653. 4p.
Publication Year :: 2002
Abstract: The model tripeptide Boc-Leu(1)-Aib(2)-Phe(3)-OMe 1 containing a non-coded amino acid residue (Aib: α-amino isobutyric acid) forms a supramolecular helical assemblage via non-covalent interactions in single crystals. The SEM image of the peptide 1 in the solid state shows the ribbon like fibrillar morphology, a characteristic feature of highly ordered aggregated fibrils like amyloid fibrils. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 43
Issue :: 14
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 7767498
Full Text :: https://doi.org/10.1016/S0040-4039(02)00283-6

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