An Interleukin-10 Gene Promoter Polymorphism (−592A/C) Associated with Type 2 Diabetes: A North Indian Study.

In this first report on the association of an IL- 10 promoter polymorphism with type 2 diabetes mellitus in a North Indian population, the −592A/C SNP (rs1800872) was genotyped by PCR-RFLP and the IL-10 level measured using ELISA. Although no significant difference was observed in the genotypic frequencies ( P = 0.657), diabetes patients carried a significantly higher number of A alleles at the −592 position, 25.6% ( P < 0.001, odds ratio 0.887, 95% CI 0.670-1.184). Significant correlations were detected in postprandial glucose levels of CC-genotype patients and controls ( P = 0.025), age and waist-hip ratio of CA patients and controls ( P ≤ 0.001), and fasting glucose ( P = 0.045) and low-density lipoprotein ( P = 0.049) in all patients and controls. The serum IL-10 level was significantly higher in patients than in controls ( P = 0.033). The polymorphism was significantly associated with disease incidence and its biochemical manifestations. [ABSTRACT FROM AUTHOR]