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<atl>Sex differences in the effects of baclofen on the acquisition of intravenous cocaine self-administration in rats
- Source :
-
Drug & Alcohol Dependence . Mar2002, Vol. 66 Issue 1, p61-69. 9p. - Publication Year :
- 2002
-
Abstract
- Baclofen, a GABAB agonist, decreases both the maintenance and reinstatement of i.v. cocaine-reinforced responding in rats. In the present experiment the effects of baclofen were extended to a comparison of male and female rats during the acquisition of i.v. cocaine self-administration. Four groups of rats were trained to self-administer i.v. cocaine (0.2 mg/kg) under a fixed-ratio 1 (FR 1) schedule using an autoshaping procedure. The criterion for acquisition was a 5-day period during which a mean of 100 cocaine infusions were administered. Rats were given 30 days to reach this criterion. Male and female groups (n=10–13) were pretreated with i.p. injections of baclofen (2.5 mg/kg) or vehicle 30-min prior to the sessions. A subset of rats (N=5) that did not acquire cocaine self-administration continued to be exposed to the acquisition procedure after baclofen treatment ended. Pretreatment with baclofen decreased both the rate of acquisition of cocaine self-administration and the percentage of rats meeting the acquisition criterion to a greater extent in females than in males. Female rats that did not meet the acquisition criterion with baclofen treatment, acquired within a few days after treatment ended. The findings confirm previous reports of enhanced acquisition of cocaine self-administration in females versus males, and they indicate that baclofen suppressed the acquisition of cocaine self-administration significantly more in females than in males. [Copyright &y& Elsevier]
- Subjects :
- *GABA agonists
*COCAINE abuse
*AUTOSHAPING (Psychology)
*LABORATORY rats
*ANIMAL experimentation
*COCAINE
*COMPARATIVE studies
*HUMAN reproduction
*INTRAVENOUS therapy
*RESEARCH methodology
*DOPAMINE uptake inhibitors
*MEDICAL cooperation
*RATS
*REACTION time
*REINFORCEMENT (Psychology)
*RESEARCH
*SELF medication
*EVALUATION research
*BACLOFEN
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 03768716
- Volume :
- 66
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Drug & Alcohol Dependence
- Publication Type :
- Academic Journal
- Accession number :
- 7754483
- Full Text :
- https://doi.org/10.1016/S0376-8716(01)00185-5