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Calcium and oxidative stress: from cell signaling to cell death
- Source :
-
Molecular Immunology . Feb2002, Vol. 38 Issue 10, p713. 9p. - Publication Year :
- 2002
-
Abstract
- Reactive oxygen and nitrogen species can be used as a messengers in normal cell functions. However, at oxidative stress levels they can disrupt normal physiological pathways and cause cell death. Such a switch is largely mediated through Ca2+ signaling. Oxidative stress causes Ca2+ influx into the cytoplasm from the extracellular environment and from the endoplasmic reticulum or sarcoplasmic reticulum (ER/SR) through the cell membrane and the ER/SR channels, respectively. Rising Ca2+ concentration in the cytoplasm causes Ca2+ influx into mitochondria and nuclei. In mitochondria Ca2+ accelerates and disrupts normal metabolism leading to cell death. In nuclei Ca2+ modulates gene transcription and nucleases that control cell apoptosis. Both in nuclei and cytoplasm Ca2+ can regulate phosphorylation/dephosphorylation of proteins and can modulate signal transduction pathways as a result. Since oxidative stress is associated with many diseases and the aging process, understanding how oxidants alter Ca2+ signaling can help to understand process of aging and disease, and may lead to new strategies for their prevention. [Copyright &y& Elsevier]
- Subjects :
- *CALCIUM
*CELL physiology
Subjects
Details
- Language :
- English
- ISSN :
- 01615890
- Volume :
- 38
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Molecular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7752548
- Full Text :
- https://doi.org/10.1016/S0161-5890(01)00108-0