Solid–Liquid Equilibriumof d- and l-Tartaric Acid and Their Importance forEnantioseparation.

The solid–liquid phase equilibrium of d- and l-tartaric acid (TA) was investigated in this work.Based onthe solubility data, the dissolution enthalpy and entropy of the monohydrateracemic tartaric acid (race-TA) and enantiomer were calculated usingvan't Hoff plots. Binary melting point phase diagrams of d- and l-TA and ternary phase diagrams of d-TA/water/l-TA were also described. The results show that TA exhibitsa racemic compound behavior. Furthermore, the influence of temperatureon the eutectic points between enantiomer and racemic compounds wasinvestigated. Finally, the importance of solid–liquid equilibriumon the purification and separation of enantiomers was discussed. [ABSTRACT FROM AUTHOR]