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E-beam crosslinked, biocompatible functional hydrogels incorporating polyaniline nanoparticles

E-beam crosslinked, biocompatible functional hydrogels incorporating polyaniline nanoparticles

Authors :
Dispenza, C.
Sabatino, M.-A.
Niconov, A.
Chmielewska, D.
Spadaro, G.
Source :
Radiation Physics & Chemistry. Sep2012, Vol. 81 Issue 9, p1456-1459. 4p.
Publication Year :
2012

Abstract

Abstract: PANI aqueous nanocolloids in their acid-doped, inherently conductive form were synthesised by means of suitable water soluble polymers used as stabilisers. In particular, poly(vinyl alcohol) (PVA) or chitosan (CT) was used to stabilise PANI nanoparticles, thus preventing PANI precipitation during synthesis and upon storage. Subsequently, e-beam irradiation of the PANI dispersions has been performed with a 12MeV Linac accelerator. PVA-PANI nanocolloid has been transformed into a PVA-PANI hydrogel nanocomposite by radiation induced crosslinking of PVA. CT-PANI nanoparticles dispersion, in turn, was added to PVA to obtain wall-to-wall gels, as chitosan mainly undergoes chain scission under the chosen irradiation conditions. While the obtainment of uniform PANI particle size distribution was preliminarily ascertained with laser light scattering and TEM microscopy, the typical porous structure of PVA-based freeze dried hydrogels was observed with SEM microscopy for the hydrogel nanocomposites. UV−visible absorption spectroscopy demonstrates that the characteristic, pH-dependent and reversible optical absorption properties of PANI are conferred to the otherwise optically transparent PVA hydrogels. Selected formulations have been also subjected to MTT assays to prove the absence of cytotoxicity. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0969806X
Volume :
81
Issue :
9
Database :
Academic Search Index
Journal :
Radiation Physics & Chemistry
Publication Type :
Academic Journal
Accession number :
77447341
Full Text :
https://doi.org/10.1016/j.radphyschem.2011.11.043