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Immunohistological study of a pediatric patient with plasma cell-rich acute rejection.
- Source :
-
Clinical Transplantation . Jul2012, Vol. 26 Issue Supp S24, p54-57. 4p. 1 Color Photograph, 2 Graphs. - Publication Year :
- 2012
-
Abstract
- We report here the case of a girl who developed plasma cell-rich acute rejection ( PCAR), a condition characterized by the presence of mature plasma cells infiltrating a renal allograft. The patient's creatinine level increased sharply to 4.3 mg/dL from 0.9 mg/dL at 19 months post-renal transplantation. She showed no response to methylprednisolone pulse therapy at a dose of 500 mg for three d but did show an immediate clinical and histopathological response to muromonab- CD3 ( OKT3) administration. She had two episodes of PCAR recurrence and subsequently lost her graft. She had no evidences of antibody-mediated rejection including C4d deposition in peritubular capillaries and donor-specific antibodies during the entire follow-up period. To elucidate the pathogenesis of PCAR, immunohistological examination of infiltrating cells was performed. CD3-positive cells infiltration seemed to be associated with the CD138-positive cells infiltration, and the number of CD3-positive cells was increased preceding PCAR recurrence. Additionally, a rapid decrease in the number of CD138-positive cells and CD3-positive cells following the OKT3 administration was observed. This case suggests that T-cell mediated immune mechanisms might play a role in the development of PCAR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09020063
- Volume :
- 26
- Issue :
- Supp S24
- Database :
- Academic Search Index
- Journal :
- Clinical Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 77406396
- Full Text :
- https://doi.org/10.1111/j.1399-0012.2012.01638.x