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Bioactivity Guided Fractionation in Experimentally Induced Hyperlipidemia in Rats and Characterization of Phytoconstituent from Solanum nigrum.
- Source :
-
Journal of Herbs, Spices & Medicinal Plants . 2012, Vol. 18 Issue 3, p257-267. 11p. 5 Black and White Photographs, 1 Diagram, 5 Charts. - Publication Year :
- 2012
-
Abstract
- The antihyperlipidemic effect of ethanolic extract of seeds of Solanum nigrum L. and its chloroform fraction was explored in Triton induced hyperlipidemic rats. Bioactivity guided fractionation followed by flash chromatography of the most active fraction resulted in the isolation of Stigmast-5, 22-dien-3β-ol. After 24 h of i.p. injection of Triton administration at 400 mg. kg-1 b.w., the extract and fraction were administered orally at doses of 200 and 400 mg. kg-1 b.w. Serum samples analyzed showed a dose dependent inhibition of the total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and increased high density lipoprotein (HDL) level. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ANIMAL experimentation
*ANALYTICAL chemistry techniques
*CHOLESTEROL
*HISTOLOGICAL techniques
*HYPERLIPIDEMIA
*LIPIDS
*BOTANIC medicine
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RATS
*SEEDS
*STAINS & staining (Microscopy)
*T-test (Statistics)
*TRIGLYCERIDES
*PLANT extracts
*DATA analysis software
*DESCRIPTIVE statistics
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 10496475
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Herbs, Spices & Medicinal Plants
- Publication Type :
- Academic Journal
- Accession number :
- 77190852
- Full Text :
- https://doi.org/10.1080/10496475.2012.688933