Effect of cellulose sulfate on the induction of hydrolysis of plasmin-specific chromogenic substrate and anticoagulant activity in rabbit blood plasma.

Rabbit plasma coagulation time in the APTT and ReaClot-heparin tests, antithrombin and anti-factor Xa activities of plasma, and the effective half-life and duration of action increase with dose (0.3 to 10 mg/kg, i.v.) of injected cellulose sulfate (molecular weight 10 - 30 kDa, degree of sulfonation 1.8, antithrombin activity 130 ± 12 IU/mg, anti-factor Xa activity 45 ± 3.3 IU/mg). Cellulose sulfate independently neither influences human platelet aggregation nor potentiates adenosinediphosphate-induced human platelet aggregation and fibrinolytic activity of plasma euglobulin fraction in vivo but it favors an increase in the fibrinolytic activity of plasma upon intravenous injection in rabbits. [ABSTRACT FROM AUTHOR]