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Association between apolipoprotein E gene polymorphism and Alzheimer's disease in Uighur and Han populations.
- Source :
-
Psychogeriatrics . Jun2012, Vol. 12 Issue 2, p83-87. 5p. 1 Diagram, 4 Charts. - Publication Year :
- 2012
-
Abstract
- Aim: Currently, there are almost 100 genes related to Alzheimer's disease (AD), and studies have indicated that apolipoprotein E (APO E) ε4 allele is a genetic risk factor of AD. However, there have been no reports of the distributions of APO E genotypes and allele frequencies in Uighur and Han AD patients. Methods: We analyzed APO E gene polymorphism in 209 AD cases diagnosed based on National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association and 220 non-dementia controls. We used polymerase chain reaction-restriction fragment length polymorphism methods as the basis of this epidemiological survey. Results: In the AD and control groups, there are no statistically significant differences in APO E genotypes and allele frequency between the Uighur and Han ethnicities ( P < 0.05). In the AD group, the ε3/4 genotype (28.2%) and ε4 allele frequency (14.8%) occurred at a higher rate than in the control (13.2% and 8.0%, respectively; P < 0.05). This distinction remained true within each ethnicity; the ε3/4 genotype and ε4 allele frequency are higher in the AD groups (Uighur, 30.6% and 15.8%, respectively; Han, 25.5% and 13.8%, respectively) than in the control groups (Uighur, 14.5% and 9.4%, respectively; Han, 11.7% and 6.3%, respectively; P < 0.05). Conclusions: The distribution of APO E genotype and allele frequency does not differ between the Uighur and Han ethnicities. The APO E ε4 allele is a risk factor of AD for both populations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13463500
- Volume :
- 12
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Psychogeriatrics
- Publication Type :
- Academic Journal
- Accession number :
- 76918591
- Full Text :
- https://doi.org/10.1111/j.1479-8301.2011.00389.x